BLZ945

CAS NO.：953769-46-5

Cat NO.：BCP14029

Name：BLZ945

Synonyms：BLZ 945; BLZ-945;Sotuletinib

Formula：C20H22N4O3S

M. Wt：398.48

Purity：95%

Pathways：Angiogenesis/Protein Tyrosine Kinase 

Targets：cFMS 

Storage：Store at 4-8°C

Description：BLZ945 is a potent and selective CSF-1R kinase inhibitor. BLZ945 showed effects of CSF1R inhibition on other tumor-infiltrating immune cells. BLZ945 attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas. BLZ945 decreases the growth of malignant cells in the mouse mammary tumor virus-driven polyomavirus middle T antigen (MMTV-PyMT) model of mammary carcinogenesis. BLZ945 prevents tumor progression in the keratin 14-expressing human papillomavirus type 16 (K14-HPV-16) transgenic model of cervical carcinogenesis.