Vimseltinib

CAS NO.：1628606-05-2

Cat NO.：BCP44095

Name：Vimseltinib

Synonyms：DCC-3014; DCC 3014; DCC3014

Formula：C23H25N7O2

M. Wt：431.49

Purity：98%

Pathways：Angiogenesis/Protein Tyrosine Kinase 

Targets：c Kit cFMS 

Storage：Store at 4-8°C

Description：Vimseltinib, also known as DCC-3014, is a potent and orally active inhibitor of the tyrosine kinase receptor colony stimulating factor 1 receptor (CSF1R; CSF-1R; C-FMS; CD115; M-CSFR), with potential antineoplastic, macrophage checkpoint-inhibitory and immunomodulating activities. Upon administration, DCC-3014 targets and binds to CSF1R expressed on monocytes, macrophages, and osteoclasts and inhibits the binding of the CSF1R ligands colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34), to CSF1R. This prevents CSF1R activation and CSF1R-mediated signaling in these cells. This blocks the production of inflammatory mediators by macrophages and monocytes and reduces inflammation.