甘氨鹅脱氧胆酸

CAS号：640-79-9

货号：BCP49686

中文名：甘氨鹅脱氧胆酸

英文名：Glycochenodeoxycholic acid

中文别名：甘鹅去氧胆酸;甘氨鹅去氧胆酸

英文别名：GCDC;Glycochenodeoxycholate;Chenodeoxycholylglycine;Glycine chenodeoxycholate

分子式：C26H43NO5

分子量：449.62

纯度：98%

信号通路：Protease/Metabolic Enzyme Apoptosis Pathway 

靶点：Caspase 

配送：惯例下常温包邮（限中国大陆地区）

产品描述：Glycochenodeoxycholic acid is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC).