AY 9944

CAS NO.：366-93-8

Cat NO.：BCP49752

Name：AY 9944

Synonyms：-

Formula：C22H30Cl4N2

M. Wt：464.3

Purity：98%

Pathways：Others Pathway 

Targets：Others 

Storage：Store at 4-8°C

Description：AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol.