BMS299897

CAS NO.：290315-45-6

Cat NO.：BCP06241

Name：BMS299897

Synonyms：BMS 299897;BMS-299897

Formula：C24H21ClF3NO4S

M. Wt：511.94

Purity：98%

Pathways：Protease/Metabolic Enzyme Neuro Signaling Pathway Wnt/Stem Cell 

Targets：Gamma secretase 

Storage：Store at 4-8°C

Description：BMS 299897 is a selective inhibitor for gamma-secretase. Reductions in the formation of Abeta peptides by gamma-secretase inhibitors may be a viable therapy for reducing Abeta in Alzheimer's disease. BMS-299897 is a gamma-secretase inhibitor that was effective in reducing amyloid beta-peptide (A beta) in transgenic mice and guinea pigs. in vitro: BMS-299897 dose-dependently increased brain concentrations of APP carboxy-terminal fragments, consistent with inhibition of gamma-secretase. BMS-299897 (100 mg/kg po) reduced brain and plasma Abeta(1-40) rapidly (within 20min) and maximally within 3 h. BMS-299897 dose-dependently reduced cortical, cerebrospinal fluid (CSF), and plasma Abeta in guinea pigs with ED(50) values of 30 mg/kg intraperitoneally, without affecting CSF levels of alpha-sAPP. The reductions in cortical Abeta correlated significantly with the reductions in both plasma (r(2) = 0.77) and CSF (r(2) = 0.61) Abeta . in vivo: BMS-299897blocked the Aβ(25-35)-induced deficits in s