Belnacasan

CAS NO.：273404-37-8

Cat NO.：BCP02893

Name：Belnacasan

Synonyms：VX-765;VX 765;VX765

Formula：C24H33ClN4O6

M. Wt：508.99

Purity：98%

Pathways：Protease/Metabolic Enzyme Apoptosis Pathway 

Targets：Caspase 

Storage：Store at 4-8°C

Description：Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM.